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Esta sobreexpresin de SLGT2 aumenta el transporte mximo (Tm) para la glucosa a valores 40-60mg/dl ms altos que el umbral fisiolgico de saturacin (glicemia180mg/dl en sujetos sanos a 240mg/dl en DM2) de manera que la glucosuria se inicia a partir de niveles glicmicos ms elevados a los esperados, lo que se traduce en una mayor reabsorcin de glucosa contribuyendo a mantener la hiperglicemia101,102,106

GK diabetic rats subjected to controlled exercise regimens demonstrated that increased oxidative stress due to increased production of reactive oxygen species (ROS), lipid/protein peroxidation, and nitric oxide (NO) production resulted in alterations in glutathione (GSH)-dependent antioxidant defense metabolism which protects the pancreas from diabetes-induced pathological changes (Raza et al., 2016)

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Rajasekaran A, Venkatasubramanian G, Berk M, Debnath M